Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5
Our study reveals that macrophages in Pg-associated PD undergo apoptosis and generate miR-143-3p-enriched ApoVs to silence IGFBP5, resulting in the perturbation of osteogenic-osteoclastic balance and the ensuing periodontal bone destruction. Accordingly, interventions targeting miR-143-3p in macrophages or employment of apoptosis inhibitor Z-VAD hold promise as effective therapeutic strategies for the management of PD.
Authors
- Qiudong Yang
- Heyu Liu (ORCID: https://orcid.org/0000-0003-1125-9862)
- Xin Huang (ORCID: https://orcid.org/0000-0002-4063-5292)
- Zhengguo Cao (ORCID: https://orcid.org/0000-0002-4261-9034)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0001-8702-5291)
- Jirong Xie
- Yifei Deng (ORCID: https://orcid.org/0000-0002-6236-8017)
- Junhong Xiao (ORCID: https://orcid.org/0009-0002-3357-2702)
Institutions
- Qingdao University (CN)
- Wuhan University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-26
- DOI
- https://doi.org/10.1186/s12951-024-02934-2
- Citations
- 14
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 5.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province