Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia
Multiple infusions of MSCs led to histological changes in the CC and neural tracts within the CC. These results indicate that multiple systemic infusions of MSCs had a greater beneficial effect in the acute phase of MCAO than a single standard or high-dose infusion of MSCs.
Authors
- Hiroshi Nagahama
- Yuko Kataoka-Sasaki (ORCID: https://orcid.org/0000-0003-4562-491X)
- Masanori Sasaki (ORCID: https://orcid.org/0000-0001-7961-9698)
- Takahiro Yokoyama (ORCID: https://orcid.org/0000-0002-5555-4495)
- Ryo Ukai (ORCID: https://orcid.org/0000-0002-8391-2552)
- Osamu Honmou (ORCID: https://orcid.org/0000-0001-8697-7530)
- Shinichi Oka (ORCID: https://orcid.org/0000-0002-3820-3394)
- Jeffery D. Kocsis
Institutions
- Sapporo Medical University (JP)
- Yale University (US)
- VA Connecticut Healthcare System (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2024-10-01
- DOI
- https://doi.org/10.3171/2024.6.jns241111
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.39