Assessment of inverse publication bias in safety outcomes: an empirical analysis
Our findings provide supporting evidence of IPB in the SMART Safety dataset of adverse events. They also suggest the importance of researchers carefully accounting for the direction of statistical tests for IPB, as well as the challenges of assessing IPB using statistical methods, especially considering that the number of studies is typically small. Qualitative assessments may be a necessary supplement to gain a more comprehensive understanding of IPB.
Authors
- Linyu Shi (ORCID: https://orcid.org/0000-0002-1588-8693)
- Jianan Zhu (ORCID: https://orcid.org/0000-0002-6582-7071)
- Lifeng Lin (ORCID: https://orcid.org/0000-0002-3562-9816)
- Chang Xu (ORCID: https://orcid.org/0000-0002-2627-1250)
- Xing Xing
Institutions
- University of Arizona (US)
- Johns Hopkins University (US)
- Second Military Medical University (CN)
- AbbVie (United States) (US)
- Eastern Hepatobiliary Surgery Hospital (CN)
- New York University (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s12916-024-03707-2
- Citations
- 4
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Arizona Biomedical Research Commission
- National Institute of Mental Health
- U.S. National Library of Medicine