<i>GLP1R</i> Gene Expression and Kidney Disease Progression
In this genetic association study, higher GLP1R gene expression was associated with a small reduction in risk of kidney disease progression. These findings support pleiotropic nephroprotective mechanisms of GLP-1RAs independent of their effects on body weight and glycemic control.
Authors
- Peter W.F. Wilson (ORCID: https://orcid.org/0000-0002-5653-7056)
- Sunil K. Ahuja (ORCID: https://orcid.org/0000-0002-6001-6181)
- Lori Churby
- Luis E. Selva (ORCID: https://orcid.org/0000-0002-3098-3832)
- Michael E. Matheny (ORCID: https://orcid.org/0000-0003-3217-4147)
- F. A. Gesek
- Elizabeth Bast (ORCID: https://orcid.org/0000-0003-2442-9437)
- Jessica V. Brewer
- Maureen Murdoch
- Jefferson L. Triozzi (ORCID: https://orcid.org/0000-0002-3607-6838)
- Kristin Mattocks (ORCID: https://orcid.org/0000-0002-6012-3008)
- Samuel M. Aguayo
- Peter S. Liang (ORCID: https://orcid.org/0000-0002-4160-421X)
- Robin A. Hurley (ORCID: https://orcid.org/0009-0002-1720-9348)
- Zuhair K. Ballas (ORCID: https://orcid.org/0000-0001-5569-1230)
- Otis D. Wilson
- X. Michelle Androulakis (ORCID: https://orcid.org/0000-0002-1833-3474)
- Michael Ong (ORCID: https://orcid.org/0000-0001-8530-7754)
- Pran Iruvanti
- Paul N. Meyer
- Sujata Bhushan
- Gerald W. Dryden (ORCID: https://orcid.org/0000-0001-9787-4537)
- Scott L. DuVall (ORCID: https://orcid.org/0000-0002-4898-3865)
- Jennifer Greco (ORCID: https://orcid.org/0000-0002-4649-1568)
- Ayush Giri (ORCID: https://orcid.org/0000-0002-7786-4670)
- Scott Kinlay (ORCID: https://orcid.org/0000-0001-7687-9136)
- Samuel Poon (ORCID: https://orcid.org/0000-0003-1284-7906)
- Sumitra Muralidhar (ORCID: https://orcid.org/0000-0001-8417-9068)
- T. Alp İkizler (ORCID: https://orcid.org/0000-0002-5717-4218)
- Jack Lichy
- Olaoluwa O. Okusaga (ORCID: https://orcid.org/0000-0002-4263-9086)
- Brian R. Ferolito (ORCID: https://orcid.org/0000-0003-3208-6446)
- Kelly Cho (ORCID: https://orcid.org/0000-0003-1727-7076)
- Jonathan P. Moorman (ORCID: https://orcid.org/0000-0002-6102-6541)
- Jennifer E. Deen
- Zhihong Yu (ORCID: https://orcid.org/0000-0003-1533-3732)
- Louis J. Dell’Italia (ORCID: https://orcid.org/0000-0001-6654-0665)
- Elvis A. Akwo (ORCID: https://orcid.org/0000-0001-9572-9184)
- Jeff Whittle (ORCID: https://orcid.org/0000-0002-9544-838X)
- Daniel J. Hogan (ORCID: https://orcid.org/0000-0001-5828-0381)
- Salvador Gutierrez
- Mark B. Hamner (ORCID: https://orcid.org/0000-0002-0532-8764)
- Richard J. Servatius (ORCID: https://orcid.org/0000-0002-7023-4895)
- Hua‐Chang Chen (ORCID: https://orcid.org/0000-0003-0497-2483)
- Shahpoor Alex Shayan
- Saiju Pyarajan (ORCID: https://orcid.org/0000-0002-9047-3762)
- Adriana M. Hung (ORCID: https://orcid.org/0000-0002-3203-1608)
- Philip S. Tsao (ORCID: https://orcid.org/0000-0001-7274-9318)
- Brady M. Stephens
- Ismene Petrakis
- Elizabeth R. Hauser (ORCID: https://orcid.org/0000-0003-0367-9189)
- Andrew W. Yen (ORCID: https://orcid.org/0000-0002-7387-6789)
- Suthat Liangpunsakul (ORCID: https://orcid.org/0000-0002-6504-8123)
- Lawrence S. Phillips (ORCID: https://orcid.org/0000-0002-6542-8046)
- Todd Gress
- Edward J. Boyko (ORCID: https://orcid.org/0000-0002-3695-192X)
- Amy M. Kilbourne (ORCID: https://orcid.org/0000-0001-5815-6401)
- Providencia Morales
- Patrick J. Strollo
- Tze Shien Lo (ORCID: https://orcid.org/0000-0003-4737-9954)
- Todd Connor
- Michael Rauchman (ORCID: https://orcid.org/0000-0002-4820-3689)
- Gerardo Villareal
- L. Christine Faulk (ORCID: https://orcid.org/0000-0002-9355-4525)
- Jean C. Beckham (ORCID: https://orcid.org/0000-0001-8746-8949)
- Darshana Jhala (ORCID: https://orcid.org/0000-0002-4940-4431)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
- Timothy R. Morgan (ORCID: https://orcid.org/0000-0003-1328-0307)
- Stacey B. Whitbourne (ORCID: https://orcid.org/0000-0002-3472-3464)
- Mary T. Brophy (ORCID: https://orcid.org/0000-0003-2314-4368)
- Cassianne Robinson‐Cohen (ORCID: https://orcid.org/0000-0003-4783-7046)
- Samir Gupta (ORCID: https://orcid.org/0000-0003-2656-3912)
- Daryl Fujii (ORCID: https://orcid.org/0000-0001-7887-3352)
- Mary A. Whooley (ORCID: https://orcid.org/0000-0002-5943-0078)
- Eknath Naik
- Dean P. Argyres
- Joseph Fayad
- Saib Gappy
- Peruvemba Sriram (ORCID: https://orcid.org/0000-0002-6103-3573)
- Kathrina Alexander
- Frank J. Jacono
- Ran Tao (ORCID: https://orcid.org/0000-0001-5461-5930)
- David Cohen (ORCID: https://orcid.org/0000-0001-7318-8567)
- Neeraj Tandon (ORCID: https://orcid.org/0000-0002-8108-698X)
- Seema Joshi (ORCID: https://orcid.org/0000-0002-5091-1553)
- Satish Sharma
- Tim Assimes
- John Michael Gaziano
- Prakash Balasubramanian
- Jennifer Moser
- Alexandre C. Pereira (ORCID: https://orcid.org/0009-0000-2103-2480)
- J. Michael Gaziano
- Michael Godschalk
- Adriana M. Hung
- River Smith (ORCID: https://orcid.org/0000-0002-0071-9715)
- Michael Landry
- Stephen Mastorides
- Kris Ann Oursler
- Shing Shing Yeh
- Junzhe Xu
- John B. Harley
- John M. Wells
- Dave Oslin
- Ronnie Marrache
- Jessica Walsh
- Charles S. Mahan
- James Norton
- S. Amneet
Institutions
- Brigham and Women's Hospital (US)
- Emory University (US)
- Vanderbilt University (US)
- VA Boston Healthcare System (US)
- VA Tennessee Valley Healthcare System (US)
- Nashville VA Medical Center (US)
- Atlanta VA Health Care System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.40286
- Citations
- 6
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.15