<i>GLP1R</i> Gene Expression and Kidney Disease Progression

In this genetic association study, higher GLP1R gene expression was associated with a small reduction in risk of kidney disease progression. These findings support pleiotropic nephroprotective mechanisms of GLP-1RAs independent of their effects on body weight and glycemic control.

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Publication Details

Journal
JAMA Network Open
Published
2024-10-25
DOI
https://doi.org/10.1001/jamanetworkopen.2024.40286
Citations
6
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
2.15
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GLP1R Gene Expression and Kidney Disease Progression

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GLP1R Gene Expression and Kidney Disease Progression

Peter W.F. Wilson, Sunil K. Ahuja, Lori Churby, Luis E. Selva, Michael E. Matheny, F. A. Gesek, Elizabeth Bast, Jessica V. Brewer, Maureen Murdoch, Jefferson L. Triozzi, Kristin Mattocks, Samuel M. Aguayo, Peter S. Liang, Robin A. Hurley, Zuhair K. Ballas, Otis D. Wilson, X. Michelle Androulakis, Michael Ong, Pran Iruvanti, Paul N. Meyer, Sujata Bhushan, Gerald W. Dryden, Scott L. DuVall, Jennifer Greco, Ayush Giri, Scott Kinlay, Samuel Poon, Sumitra Muralidhar, T. Alp İkizler, Jack Lichy, Olaoluwa O. Okusaga, Brian R. Ferolito, Kelly Cho, Jonathan P. Moorman, Jennifer E. Deen, Zhihong Yu, Louis J. Dell’Italia, Elvis A. Akwo, Jeff Whittle, Daniel J. Hogan, Salvador Gutierrez, Mark B. Hamner, Richard J. Servatius, Hua‐Chang Chen, Shahpoor Alex Shayan, Saiju Pyarajan, Adriana M. Hung, Philip S. Tsao, Brady M. Stephens, Ismene Petrakis, Elizabeth R. Hauser, Andrew W. Yen, Suthat Liangpunsakul, Lawrence S. Phillips, Todd Gress, Edward J. Boyko, Amy M. Kilbourne, Providencia Morales, Patrick J. Strollo, Tze Shien Lo, Todd Connor, Michael Rauchman, Gerardo Villareal, L. Christine Faulk, Jean C. Beckham, Darshana Jhala, Henry R. Kranzler, Timothy R. Morgan, Stacey B. Whitbourne, Mary T. Brophy, Cassianne Robinson‐Cohen, Samir Gupta, Daryl Fujii, Mary A. Whooley, Eknath Naik, Dean P. Argyres, Joseph Fayad, Saib Gappy, Peruvemba Sriram, Kathrina Alexander, Frank J. Jacono, Ran Tao, David Cohen, Neeraj Tandon, Seema Joshi, Satish Sharma, Tim Assimes, John Michael Gaziano, Prakash Balasubramanian, Jennifer Moser, Alexandre C. Pereira, J. Michael Gaziano, Michael Godschalk, Adriana M. Hung, River Smith, Michael Landry, Stephen Mastorides, Kris Ann Oursler, Shing Shing Yeh, Junzhe Xu, John B. Harley, John M. Wells, Dave Oslin, Ronnie Marrache, Jessica Walsh, Charles S. Mahan, James Norton, S. Amneet
article en
6 citations

Abstract

In this genetic association study, higher GLP1R gene expression was associated with a small reduction in risk of kidney disease progression. These findings support pleiotropic nephroprotective mechanisms of GLP-1RAs independent of their effects on body weight and glycemic control.

JAMA Network OpenVol. 7(10)
Brigham and Women's Hospital (US), Emory University (US), Vanderbilt University (US), VA Boston Healthcare System (US), VA Tennessee Valley Healthcare System (US), Nashville VA Medical Center (US), Atlanta VA Health Care System (US), Vanderbilt University Medical Center (US)
Good health and well-being
Openalex Percentile: Top 11%
Diabetes Treatment and Management
2.15
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