Differential Effect of Aldosterone or Mineralocorticoid Receptor Overexpression on Retinal Inflammation
Consequences of hMR overexpression or aldosterone-injection on retinal transcriptome reveal very distinct pathological mechanisms, with only a few common genes regulated, most of them not being regulated in the same way. Although aldosterone is highly proinflammatory in the retina, MR overactivation in its physiologic milieu mediates a low-grade inflammation in the neural retina.
Authors
- Francine Béhar‐Cohen (ORCID: https://orcid.org/0000-0001-8571-9513)
- Chadi Mehanna
- Miguel Berdugo (ORCID: https://orcid.org/0000-0003-1053-8907)
- Théano Irinopoulou
- Bastien Leclercq (ORCID: https://orcid.org/0000-0001-6537-5397)
- Min Zhao (ORCID: https://orcid.org/0000-0002-5418-7275)
- Frédéric Jaisser (ORCID: https://orcid.org/0000-0001-9051-1901)
- Dan Mejlachowicz (ORCID: https://orcid.org/0000-0003-3824-3342)
- Laurent Jonet (ORCID: https://orcid.org/0000-0003-4485-2582)
- Linxin Zhu (ORCID: https://orcid.org/0000-0002-8235-0105)
Institutions
- Hôpital américain de paris (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut du Fer à Moulin (FR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1167/iovs.65.12.39
- Citations
- 4
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Université Paris-Saclay