Antimicrobial activity of ceftibuten/polymyxin B combination against polymyxin/carbapenem-resistant <i>Klebsiella pneumoniae</i>

The ceftibuten/polymyxin B combination exhibited synergistic effects in vitro and in vivo, and thus might be a promising therapeutic alternative for treating PC-R K. pneumoniae infections. As the combination was efficacious in preclinical models, researchers may further investigate its potential in clinical studies.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2024-10-25
DOI
https://doi.org/10.1093/jac/dkae382
Citations
5
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
0.85

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article

Antimicrobial activity of ceftibuten/polymyxin B combination against polymyxin/carbapenem-resistant Klebsiella pneumoniae

Thiago Mendonça de Aquino, Kadja Luana Chagas Monteiro, Sibele Borsuk, Aline Andrade Martins et al.
5 citations
Journal of Antimicrobial Chemotherapy
Antibiotic Resistance in Bacteria
0.85
article

Antimicrobial activity of ceftibuten/polymyxin B combination against polymyxin/carbapenem-resistant Klebsiella pneumoniae

Thiago Mendonça de Aquino, Kadja Luana Chagas Monteiro, Sibele Borsuk, Aline Andrade Martins, Mariana Carvalho Sturaro, Marcone Gomes dos Santos Alcântara, Osmar Nascimento Silva, Odir Antônio Dellagostin, Thiago Leite Fraga, Simone Simionatto, Luana Rossato, Gleyce Hellen de Almeida de Souza, Nathalia Monteiro Lins Freire, Nathalia da Silva Damaceno
article en
5 citations

Abstract

The ceftibuten/polymyxin B combination exhibited synergistic effects in vitro and in vivo, and thus might be a promising therapeutic alternative for treating PC-R K. pneumoniae infections. As the combination was efficacious in preclinical models, researchers may further investigate its potential in clinical studies.

Journal of Antimicrobial ChemotherapyVol. 80(1)
Universidade Federal de Pelotas (BR), Universidade Federal da Grande Dourados (BR), Universidade Evangelica de Goiás (BR), Universidade Estadual de Goiás (BR), Centro Universitário da Grande Dourados (BR), Universidade Federal de Alagoas (BR)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
Good health and well-being
Openalex Percentile: Top 30%
Antibiotic Resistance in Bacteria
0.85
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