Hippocampal synchronization in a realistic CA1 neuron model

This work delves into studying the synchronization in two realistic neuron models using Hodgkin-Huxley dynamics. Unlike simplistic pointlike models, excitatory synapses are here randomly distributed along the dendrites, introducing strong stochastic contributions into their signal propagation. To focus on the role of different synaptic locations, we use two copies of the same neuron whose synapses are located at different distances from the soma and activated by identical Poisson distributed pulses. The synchronization is investigated through a specifically defined spiking correlation function, and its behavior is analyzed as a function of several parameters: inhibition weight, distance from the soma of one synaptic group, weight and decay time constants of the excitatory synapses.

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Publication Details

Journal
Physical review. E
Published
2024-10-25
DOI
https://doi.org/10.1103/physreve.110.044406
Citations
1
Primary Topic
Neural dynamics and brain function
Type
article
Field-Weighted Citation Impact
0.34

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article

Hippocampal synchronization in a realistic CA1 neuron model

A. Fiasconaro, Michele Migliore
1 citations
Physical review. E
Neural dynamics and brain function
0.34
article

Hippocampal synchronization in a realistic CA1 neuron model

A. Fiasconaro, Michele Migliore
article en
1 citations

Abstract

This work delves into studying the synchronization in two realistic neuron models using Hodgkin-Huxley dynamics. Unlike simplistic pointlike models, excitatory synapses are here randomly distributed along the dendrites, introducing strong stochastic contributions into their signal propagation. To focus on the role of different synaptic locations, we use two copies of the same neuron whose synapses are located at different distances from the soma and activated by identical Poisson distributed pulses. The synchronization is investigated through a specifically defined spiking correlation function, and its behavior is analyzed as a function of several parameters: inhibition weight, distance from the soma of one synaptic group, weight and decay time constants of the excitatory synapses.

Physical review. EVol. 110(4)
Universidad de Zaragoza (ES), Instituto di Biofisica (ES), Consorzio Roma Ricerche (IT), Biocom (US), National Research Council (IT), Instituto de Biocomputación y Física de Sistemas Complejos
Ministerio de Ciencia e Innovación
Openalex Percentile: Top 39%
Neural dynamics and brain function
0.34
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Hippocampal synchronization in a realistic CA1 neuron model — A. Fiasconaro, Michele Migliore · Physical review. E (2024) | TGRS Research Map | TGRS