Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients
New protocol to isolate synaptic and extrasynaptic membranes from the human cortex. Low GluN2B and GluN2A levels in Alzheimer´s disease (AD) synaptic membranes. High GluN2B and GluN1 levels in AD extrasynaptic membranes. Specific glycoforms of extrasynaptic GluN2B and GluN2A. Low phosphorylation at Tyr1472 in synaptic GluN2B in AD.
Authors
- Javier Sáez‐Valero (ORCID: https://orcid.org/0000-0001-7480-320X)
- Isabel Pérez‐Otaño (ORCID: https://orcid.org/0000-0002-7222-8202)
- Montse Solé (ORCID: https://orcid.org/0000-0003-4240-6562)
- Sergio Escamilla (ORCID: https://orcid.org/0000-0003-0952-7506)
- Joan X. Comella (ORCID: https://orcid.org/0000-0002-6218-0786)
- Jose Vicente Sanchez Mut
- Inmaculada Cuchillo‐Ibáñez (ORCID: https://orcid.org/0000-0002-3689-5518)
- Raquel Badillos
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital Sant Joan de Déu Barcelona (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Neurociencias (ES)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
- Institut de Recerca Sant Joan de Déu
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1002/alz.14125
- Citations
- 27
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 7.24
Funders
- Generalitat Valenciana
- Xarxa de Bancs de Tumors de Catalunya
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación