Identification of vancomycin exposure target in neonates: how much is enough?
AUC0-24h/MIC ≥ 331 was the optimal target of vancomycin efficacy in neonates. The trough concentration was not a reliable predictor of efficacy and AUC0-24h/MIC. AUC-guided dosage adjustments are more valuable in clinical applications.
Authors
- Xingfang Ji
- Changjiang Wang (ORCID: https://orcid.org/0000-0002-0425-7976)
- Zhipeng Wang (ORCID: https://orcid.org/0000-0001-9974-1703)
- Fan Wang (ORCID: https://orcid.org/0009-0000-1405-776X)
- Tong Wu (ORCID: https://orcid.org/0000-0002-9878-4821)
- Xia Song
- Qiu Wen
- Yuan Gao (ORCID: https://orcid.org/0009-0005-3123-3207)
- Libin Pu
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1093/jac/dkae374
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.39