Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer
Among patients with high-risk or metastatic prostate cancer who were initially diagnosed with and treated for nonmetastatic tumors, germline DNA repair variants in BRCA2 do not confer a substantially worse prognosis.
Authors
- Kenneth Offit (ORCID: https://orcid.org/0000-0002-2180-2032)
- Joseph Vijai (ORCID: https://orcid.org/0000-0002-7933-151X)
- Mark M. Pomerantz
- Michael J. Morris (ORCID: https://orcid.org/0000-0002-9454-0096)
- Michael Conry (ORCID: https://orcid.org/0000-0003-1904-8947)
- Gwo‐Shu Mary Lee (ORCID: https://orcid.org/0000-0001-9236-9195)
- Yelena M. Kemel (ORCID: https://orcid.org/0000-0002-5042-5651)
- Samantha E. Vasselman (ORCID: https://orcid.org/0009-0003-6903-1884)
- Dory Freeman (ORCID: https://orcid.org/0000-0003-2617-0641)
- Lorelei Ann Mucci (ORCID: https://orcid.org/0000-0002-2551-4927)
- Kathryn L. Penney (ORCID: https://orcid.org/0000-0002-2815-3450)
- Konrad Hermann Stopsack (ORCID: https://orcid.org/0000-0002-0722-1311)
- Philip W. Kantoff (ORCID: https://orcid.org/0000-0001-7275-0597)
- Jacob E. Berchuck (ORCID: https://orcid.org/0000-0002-7607-2428)
- Wassim Abida (ORCID: https://orcid.org/0000-0002-9006-7043)
- Diana L. Mandelker (ORCID: https://orcid.org/0000-0003-4154-0567)
- David B. Solit (ORCID: https://orcid.org/0000-0002-6614-802X)
Institutions
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Emory University (US)
- Cornell University (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
- Convergent Science (United States) (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2483
- Citations
- 8
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- Prostate Cancer Foundation
- Dana-Farber/Harvard Cancer Center
- National Cancer Institute