Didang Tang alleviates neuronal ferroptosis after intracerebral hemorrhage by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway
DDT alleviates neuronal ferroptosis after ICH by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway. Overall, this study provides novel insights into DDT's protective mechanisms against ICH-induced neuronal injury by modulating ferroptosis and ERS pathways, underscoring its potential as an effective therapeutic strategy.
Authors
- Xiaolei Tang (ORCID: https://orcid.org/0000-0001-8521-6406)
- Peng Xu (ORCID: https://orcid.org/0000-0003-0822-700X)
- Jing Lü (ORCID: https://orcid.org/0000-0001-5766-2775)
- Hanying Xu
- Liwei Sun (ORCID: https://orcid.org/0000-0003-4194-1889)
- Dongmei Zhang (ORCID: https://orcid.org/0000-0002-4132-7363)
- Li Li (ORCID: https://orcid.org/0000-0003-4151-967X)
- Jian Wang (ORCID: https://orcid.org/0000-0003-2291-640X)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-1289-5978)
Institutions
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fphar.2024.1472813
- Citations
- 11
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China