Predicting acute lung injury in infants with congenital heart disease after cardiopulmonary bypass by gut microbiota
Our study suggests that postoperative ALI patients have distinct gut microbiota upon admission compared to non-ALI patients after surgery. Dysbiosis of the gut microbiota may potentially impact the progression of ALI through metabolic pathways, quorum sensing, and the levels of inflammatory factors expressed in the serum. <i>Escherichia Shigella</i> represents a potential predictive factor for the occurrence of ALI in CHD infants after surgery. Acute lung injury, congenital heart disease, cardiopulmonary bypass surgery, gut microbiota, biomarker.
Authors
- Kaiqin Wu (ORCID: https://orcid.org/0000-0003-2468-9458)
- Xinyu Cai (ORCID: https://orcid.org/0000-0003-4994-0645)
- Jirong Qi (ORCID: https://orcid.org/0000-0003-4263-0265)
- Yueshuang Cun
- Menglong Hu (ORCID: https://orcid.org/0000-0002-8419-613X)
- Tianyi Zhu (ORCID: https://orcid.org/0000-0001-9291-8975)
- Nishant Patel (ORCID: https://orcid.org/0000-0002-2420-4484)
- Lan Jiang
- Qiang Wang (ORCID: https://orcid.org/0000-0003-1090-2174)
- Zhaocong Yang (ORCID: https://orcid.org/0000-0002-2133-2333)
- Xuming Mo
- Zhen Wu (ORCID: https://orcid.org/0000-0002-8870-500X)
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1362040
- Citations
- 9
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.77