Epstein-Barr virus-specific T-cell response in pediatric liver transplant recipients: a cross-sectional study by multiparametric flow cytometry
Polyfunctional CD8+ EBV-specific T-cell response allows detecting EBV previous contact in liver-transplant children. %CD8+CD107a+IFNɣ+IL2-TNFα- is increased in patients with positive viral loads. Central memory CD4+ T-cell population more effectively determines prior EBV-exposure in adults.
Authors
- Ana Martínez‐Feito (ORCID: https://orcid.org/0000-0002-5580-8387)
- Keren Reche-Yebra
- Esteban Frauca-Remacha
- Almudena Gutiérrez-Arroyo (ORCID: https://orcid.org/0000-0001-6815-2623)
- Gema Muñoz-Bartolo (ORCID: https://orcid.org/0000-0002-6207-7463)
- Elena Sánchez‐Zapardiel (ORCID: https://orcid.org/0000-0002-1017-0340)
- Laura Miguel‐Berenguel
- Ricardo Cuesta‐Martín de la Cámara (ORCID: https://orcid.org/0000-0002-2556-8992)
- Eduardo López‐Granados (ORCID: https://orcid.org/0000-0002-3646-3870)
- Andrea Torices-Pajares
- Loreto Hierro-Llanillo
- María Dolores Lledín-Barbacho
Institutions
- Hospital Universitario La Paz (ES)
- Hospital La Paz Institute for Health Research (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- ERN GUARD-Heart (NL)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1479472
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- European Commission
- Instituto de Salud Carlos III