Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten
In our cohort of RRF patients, we observed a significantly higher prevalence of HLA susceptibility genes for CD/NCGS compared to the general population, also associated with a higher incidence of thyroid alterations. A gluten-free diet and the use of levothyroxine in cases of thyroid pathology had significant beneficial effects on pregnancy outcomes. We suggest that HLA typing for CD/NCGS and a gluten-free diet, in the presence of risk alleles, can improve pregnancy outcomes in RRF patients.
Authors
- Ricardo Savirón‐Cornudella (ORCID: https://orcid.org/0000-0001-9585-0187)
- Silvia Sánchez‐Ramón (ORCID: https://orcid.org/0000-0001-9585-6167)
- Ignacio Cristóbal García (ORCID: https://orcid.org/0000-0002-2793-6592)
- Noelia Pérez (ORCID: https://orcid.org/0009-0002-8707-8865)
- Raquel Gil Laborda
- Teresa Gastañaga-Holguera (ORCID: https://orcid.org/0000-0002-7130-0137)
- Kissy Guevara‐Hoyer (ORCID: https://orcid.org/0000-0003-3568-8821)
- Lydia Pilar Suárez
- Marta Calvo Urrutia
- E. de la Fuente (ORCID: https://orcid.org/0000-0001-8419-679X)
- María José Mansilla (ORCID: https://orcid.org/0000-0002-5044-6313)
- Ángela Villegas
- Juliana Ochoa‐Grullón (ORCID: https://orcid.org/0000-0002-5218-7108)
- Miguel Fernández‐Arquero (ORCID: https://orcid.org/0009-0007-6213-6789)
- Marina P. Sánchez (ORCID: https://orcid.org/0000-0001-6785-7680)
- María G. Guzmán (ORCID: https://orcid.org/0000-0001-6161-9489)
- Nabil Subbhi-Issa
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital Clínico San Carlos (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fimmu.2024.1451552
- Citations
- 3
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.39