Cell-nanoparticle stickiness and dose delivery in a multi-model in silico platform: DosiGUI
Accurate nanoparticle dose estimation in vitro is crucial for in vivo extrapolation, allowing for their safe use in medical and other applications. This study provides a computational platform - DosiGUI - for more reliable dose-response characterization. It also highlights the importance of cell-nanoparticle stickiness for better risk assessment of engineered nanomaterials.
Authors
- Pietro Vagaggini (ORCID: https://orcid.org/0000-0002-0747-7245)
- Ilaria Zanoni (ORCID: https://orcid.org/0000-0001-8692-3460)
- Davide Gardini (ORCID: https://orcid.org/0000-0002-8879-6044)
- Arti Ahluwalia (ORCID: https://orcid.org/0000-0001-5370-6750)
- Lara Faccani
- Anna Luisa Costa (ORCID: https://orcid.org/0000-0003-1407-6498)
- Nicole Guazzelli
- Ermes Botte (ORCID: https://orcid.org/0000-0001-5058-5316)
Institutions
- University of Pisa (IT)
- Piaggio (Italy) (IT)
- Institute of Science and Technology for Ceramics (IT)
- National Research Council (IT)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12989-024-00607-4
- Citations
- 4
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- European Commission
- Horizon 2020 Framework Programme