Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia
Our study has some limitations, such as the small sample size, the heterogeneity in adverse events due to the patients' different regions of origin, and the limited ability to conduct a more detailed follow-up on pancreatitis. Additionally, since no significant associations were found between the <i>NFATC2</i> rs6021191 and <i>GRIA1</i> rs6889909 SNVs and the development of adverse events or the presence of antibodies due to the use of L-Asp, it is necessary to investigate new specific SNVs that may improve the efficacy and safety of treatment in Mexican children with ALL.
Authors
- Antonio Sandoval-Cabrera (ORCID: https://orcid.org/0000-0002-6359-9394)
- Jesús Alonso Gándara‐Mireles (ORCID: https://orcid.org/0000-0002-5927-4992)
- Leslie Patrón‐Romero (ORCID: https://orcid.org/0000-0001-8981-055X)
- Verónica Loera Castañeda
- Horacio Almanza‐Reyes (ORCID: https://orcid.org/0000-0002-1874-3975)
- Elio Aarón Reyes Espinoza
- Lourdes Patricia Córdova Hurtado
- Julio Cesar Grijalva Ávila (ORCID: https://orcid.org/0000-0001-5177-1188)
- Ismael Lares‐Asseff (ORCID: https://orcid.org/0000-0001-5124-4556)
- Ignacio Villanueva Fierro
- Flor de María Reyes Gutiérrez
- Claudia Castro Arreola
Institutions
- Universidad Autónoma de Baja California (MX)
- Universidad Autónoma del Estado de México (MX)
- Durango Institute of Technology (MX)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fphar.2024.1423049
- Citations
- 4
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 2.17