Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability s

The metabolic process of atorvastatin may be inhibited in uremic hemodialysis patients, but the total concentration of atorvastatin did not change significantly; due to the decrease of protein binding rate increase the drug distribution of atorvastatin in the liver or muscle tissue, which may increase the risk of certain adverse reactions. We recommend that clinicians use free drug concentration monitoring to adjust the dose of atorvastatin to ensure patient safety for uremic hemodialysis patients.

Authors

Institutions

Publication Details

Journal
Frontiers in Cardiovascular Medicine
Published
2024-10-24
DOI
https://doi.org/10.3389/fcvm.2024.1461181
Citations
1
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
0.23
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability s

Ming-Chen Cao, Xin Huang, Bo‐Hao Tang, Hai-Yan Shi et al.
1 citations
Frontiers in Cardiovascular Medicine
Metabolomics and Mass Spectrometry Studies
0.23
article

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability s

Ming-Chen Cao, Xin Huang, Bo‐Hao Tang, Hai-Yan Shi, Yi Zheng, Wei Zhao
article en
1 citations

Abstract

The metabolic process of atorvastatin may be inhibited in uremic hemodialysis patients, but the total concentration of atorvastatin did not change significantly; due to the decrease of protein binding rate increase the drug distribution of atorvastatin in the liver or muscle tissue, which may increase the risk of certain adverse reactions. We recommend that clinicians use free drug concentration monitoring to adjust the dose of atorvastatin to ensure patient safety for uremic hemodialysis patients.

Frontiers in Cardiovascular MedicineVol. 11
Qingdao University (CN), Shandong University of Traditional Chinese Medicine (CN), Shandong University (CN), Affiliated Hospital of Qingdao University (CN), Shandong Provincial QianFoShan Hospital (CN), Jimo District Qingdao Hospital of Traditional Chinese Medicine (CN), Shandong First Medical University (CN)
Openalex Percentile: Top 41%
Metabolomics and Mass Spectrometry Studies
0.23
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability s — Ming-Chen Cao, Xin Huang, et al. · Frontiers in Cardiovascular Medicine (2024) | TGRS Research Map | TGRS