Pharmacokinetics study of atracurium, dexmedetomidine, midazolam and 1-hydroxymidazolam in patients undergoing acute aortic dissection surgery
The developed UPLC-MS/MS method for simultaneous determination of ATC, DEX, MDZ and 1-OH-MDZ in patient plasma was accurate, reproducible, specific. After continuous administration of ATC, DEX, and MDZ to patients undergoing surgery for acute aortic dissection, the pharmacokinetics of ATC, DEX, MDZ and 1-OH-MDZ in patients undergoing aortic dissection surgery were studied.
Authors
- Xuanxuan Xu
- Shuaibo Shi
- Jie Hu (ORCID: https://orcid.org/0000-0002-8330-1225)
- Huiling Si
- Yongsheng Liang (ORCID: https://orcid.org/0000-0002-0891-5577)
- Fan Xie
Institutions
- Panyu Hospital of Chinese Medicine (CN)
- Luoyang Central Hospital Affiliated to Zhengzhou University (CN)
- Xian Yang Central Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fphar.2024.1427553
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Henan Provincial Science and Technology Research Project