Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy

The overall prevalence of archived INSTI RAMs in Botswana was low prior to transitioning to first-line DTG-based ART regimens, and did not differ between ART-naïve and ART-experienced individuals. Ongoing surveillance of INSTI DRMs in Botswana will allow for re-assessment of INSTI resistance risk following nationwide DTG rollout.

Authors

Catherine K. Koofhethile (ORCID: https://orcid.org/0000-0001-5475-413X)
Simani Gaseitsiwe (ORCID: https://orcid.org/0000-0002-7089-3735)
Dorcas Maruapula (ORCID: https://orcid.org/0000-0003-2587-8904)
Roger Shapiro (ORCID: https://orcid.org/0000-0002-4832-6275)
Boitumelo J.L Zuze
Shahin Lockman (ORCID: https://orcid.org/0000-0002-5384-9716)
Doreen Ditshwanelo
Natasha O. Moraka (ORCID: https://orcid.org/0000-0001-5333-4010)
Kebaneilwe Lebani (ORCID: https://orcid.org/0000-0001-8927-091X)
Ontlametse T. Bareng (ORCID: https://orcid.org/0009-0005-8147-2193)
Joseph Makhema (ORCID: https://orcid.org/0000-0003-0017-2438)
Kaelo K. Seatla (ORCID: https://orcid.org/0000-0002-2190-2842)
Wonderful Tatenda Choga (ORCID: https://orcid.org/0000-0001-7606-0569)
Vlad Novitsky
Tendani Gaolathe
Sikhulile M. Moyo (ORCID: https://orcid.org/0000-0003-3821-4592)
Patrick Mokgethi
Marea N. Pema
Molly Pretorius-Holme

Institutions

Brigham and Women's Hospital (US)
Harvard University (US)
University of Botswana (BW)
Botswana International University of Science and Technology (BW)
Botswana Harvard AIDS Institute Partnership (BW)
University of Pretoria (ZA)

Publication Details

Journal: Frontiers in Microbiology
Published: 2024-10-24
DOI: https://doi.org/10.3389/fmicb.2024.1482348
Citations: 2
Primary Topic: HIV/AIDS drug development and treatment
Type: article
Field-Weighted Citation Impact: 0.78

Funders

Bill and Melinda Gates Foundation
Wellcome Trust
European Commission
Centers for Disease Control and Prevention

Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy

Catherine K. Koofhethile, Simani Gaseitsiwe, Dorcas Maruapula, Roger Shapiro, Boitumelo J.L Zuze, Shahin Lockman, Doreen Ditshwanelo, Natasha O. Moraka, Kebaneilwe Lebani, Ontlametse T. Bareng, Joseph Makhema, Kaelo K. Seatla, Wonderful Tatenda Choga, Vlad Novitsky, Tendani Gaolathe, Sikhulile M. Moyo, Patrick Mokgethi, Marea N. Pema, Molly Pretorius-Holme

October 24, 2024article en

2 citations

Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy

Authors

Institutions

Publication Details

Funders

Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy

Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy

Abstract

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