Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae clinical isolates in bacteremia: a study in a Malaysian tertiary center
The current study provides insight into the gene carriage in <i>E.coli</i> and <i>Klebsiella species</i> clinical isolates, including <i>bla</i> <sub>CTX-M</sub> genotypes in antibiotic-susceptible strains from a Malaysian hospital. The ESBL encoding genotypes such as <i>bla</i> <sub>CTX-M</sub> presented substantially beyond one-third of the ESBL phenotype-negative or 3GC susceptible <i>E.coli</i> and <i>K.pneumoniae</i> isolated from bloodstream infection. Although clinical outcomes were not worsened with <i>bla</i> <sub>CTX-M</sub> genotype-positive but ESBL phenotype-negative isolates in bacteremia, the potential implications for AMR spread deserve further investigation.
Authors
- Petrick Periyasamy (ORCID: https://orcid.org/0000-0003-4379-9214)
- Isa Naina Mohamed (ORCID: https://orcid.org/0000-0001-8891-2423)
- Tg Mohd Ikhwan Tg Abu Bakar Sidik (ORCID: https://orcid.org/0000-0001-8192-7905)
- Ramliza Ramli (ORCID: https://orcid.org/0000-0001-5518-1601)
- Toh Leong Tan (ORCID: https://orcid.org/0000-0002-6771-0141)
- Hui‐min Neoh (ORCID: https://orcid.org/0000-0001-8445-4314)
- Chee Lan Lau
Institutions
- Hospital Kuala Lumpur (MY)
- University Kebangsaan Malaysia Medical Centre (MY)
- National Defence University of Malaysia (MY)
- IMU University (MY)
- National University of Malaysia (MY)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fcimb.2024.1429830
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68