Causal relationship between hypothyroidism and coronary atherosclerotic cardiovascular disease: a bidirectional two-sample Mendelian randomization
The marked association between hypothyroidism and CAD, AP, MI, and IS suggests that thyroid function assessment could be integral to preventing and diagnosing specific ASCVD types. This underscores the need for individuals with hypothyroidism to be proactive regarding ASCVD risk factors. A balanced Th1/Th2 and Th17/Treg ratio may offer a novel strategy in preventing CAD and enhancing the prognosis for hypothyroid patients.
Authors
- Tianwei Meng (ORCID: https://orcid.org/0000-0001-8311-6903)
- Likun Du (ORCID: https://orcid.org/0000-0002-8448-2187)
- Chengjia Li (ORCID: https://orcid.org/0000-0001-9082-2726)
- Jiarui Li (ORCID: https://orcid.org/0000-0002-9340-3962)
- Juan Li (ORCID: https://orcid.org/0000-0002-3529-178X)
- Yihan Wang (ORCID: https://orcid.org/0000-0002-1163-4610)
- Xiaoting Luo (ORCID: https://orcid.org/0009-0003-1469-9350)
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fcvm.2024.1402359
- Citations
- 5
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.79