Phenotypic and genetic characterization of daptomycin non-susceptible Staphylococcus aureus strains selected by adaptive laboratory evolution
This work validates adaptive laboratory evolution (ALE) for modeling clinical DNS strains and uncovers contributions of <i>mprF</i>, <i>cls2</i>, and <i>saeR</i> mutations to the adaptation and resistance mechanisms of <i>S. aureus</i> against daptomycin. These findings enrich our understanding of how <i>S. aureus</i> acquired resistance to daptomycin, thus paving the way for the development of more effective treatment strategies and offering potential molecular markers for resistance surveillance.
Authors
- Yanghua Xiao (ORCID: https://orcid.org/0000-0001-7417-0799)
- Huilin Zhao (ORCID: https://orcid.org/0009-0006-4449-354X)
- Bingjie Wang (ORCID: https://orcid.org/0000-0002-1199-6240)
- Fangyou Yu (ORCID: https://orcid.org/0000-0003-4924-2484)
- Ying Zhou (ORCID: https://orcid.org/0000-0002-6859-8702)
- Yinjuan Guo
- Xiaocui Wu
- Yanlei Xu
- Yongpeng Shang (ORCID: https://orcid.org/0000-0002-3348-0675)
- Jingyi Yu (ORCID: https://orcid.org/0009-0007-6187-9580)
Institutions
- Tongji University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fcimb.2024.1453233
- Citations
- 6
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 2.33