Whole genome sequencing distinguishes skin colonizing from infection-associated Cutibacterium acnes isolates
Genome-wide association studies (GWAS) from both the pangenome and SNP data consistently showed genomic differences between both groups located in metabolic pathway and DNA repair genes. Thus, the different behavior of colonizing and infectious C. acnes strains could be due to special metabolic capacities or flexibilities rather than specific virulence traits.
Authors
- Bernd Kreikemeyer (ORCID: https://orcid.org/0000-0001-9527-5098)
- Thomas Köller (ORCID: https://orcid.org/0000-0002-8150-0677)
- Philipp Warnke
- Israel Barrantes (ORCID: https://orcid.org/0000-0002-5252-4485)
- Andreas Podbielski
Institutions
- University of Rostock (DE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fcimb.2024.1433783
- Citations
- 4
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.14
Funders
- European Regional Development Fund