Assessment of Efficiency and Safety of Phytocomposition with Prostate-Protective Properties in the form of Rectal Suppositories

AIM: to evaluate the clinical efficiency of phytocomposition with prostate-protective properties in the form of rectal suppositories. METHODS: The analysis of literature information was performed to assess literature data and form an evidence base for the ratio between the levels of clinical effectiveness and safety for phytocomposition with prostate-protective properties in the form of rectal suppositories. To assess the clinical efficiency and safety the authors used a literature review on the ground of databases PubMed, MEDLINE, Web of Science, and Scopus. RESULTS: The functional characteristics of a combination of extracts of saw palmetto, lovage roots, and calendula flowers are caused by fatty acids and their derivatives (saw palmetto), essential oils, flavonoids (lovage, calendula), phenolic acids, phthalides, and bitter principles (lovage). Considering the complex effect of all components, the studied phytocomposition in the form of rectal suppositories promotes the arrest of the inflammatory process, inhibits vein micro-thrombosis in the prostate, decreases the edema and leucocytic infiltration of the prostate, and improves microcirculation processes. CONCLUSIONS: Analyzing the scientific literature on the components of phytocomposition of rectal suppositories with prostate-protective properties, it may be concluded that the combination of extracts of saw palmetto, lovage roots, and calendula flowers has anti-inflammatory, antiproliferative, and immunomodulatory action.