The decrease in Rad51 and DNA ligase IV nuclear protein expression in Msh2 knockdown HC11 cells induced the low CRISPR/Cas9-mediated knock-in efficiency at the β-casein gene locus
The decreased Msh2 protein expression in the nucleus downregulated the Rad51 and ligase IV protein expressions. Consequently, reduced Rad51 expression results in decreased knock-in efficiency.
Authors
- Man‐Jong Kang (ORCID: https://orcid.org/0000-0002-7628-0614)
- Ga-Yeon Kim
Institutions
- Chonnam National University (KR)
Publication Details
- Journal
- Animal Bioscience
- Published
- 2024-10-24
- DOI
- https://doi.org/10.5713/ab.24.0206
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea