TGF-β antagonism synergizes with PPARγ agonism to reduce fibrosis and enhance beige adipogenesis
Basal and high-fat diet inducible activation of TGF-β underlies the heterogeneity of adipose tissue depots. TGF-β/Smad3 activation promotes adipose tissue fibrosis and suppresses beige progenitors. Together, these dual mechanisms preclude functional beige adipogenesis. Controlled inhibition of TβRI signaling and concomitant PPARγ stimulation can suppress adipose tissue fibrosis and promote beige adipogenesis to improve metabolism.
Authors
- Sushil G. Rane (ORCID: https://orcid.org/0000-0002-2011-5281)
- Cheryl Cero (ORCID: https://orcid.org/0000-0003-0513-8669)
- Young Jae Bahn
- Kelly T Long (ORCID: https://orcid.org/0009-0008-2935-0430)
- Pradeep Kumar Dagur (ORCID: https://orcid.org/0000-0002-4491-0853)
- Aaron M. Cypess (ORCID: https://orcid.org/0000-0002-5570-9346)
- Yanling Wang (ORCID: https://orcid.org/0000-0003-4338-2224)
- Nicholas Scott (ORCID: https://orcid.org/0000-0001-8495-8547)
- Nhuquynh Nguyen
Institutions
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- National Heart, Lung, and Blood Institute (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.molmet.2024.102054
- Citations
- 12
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Colgate University
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases