Antibody-Drug Conjugates in the Treatment of Metastatic Breast Cancer: The Emerging Questions of Sequence and Resistance

Metastatic breast cancer continues to present significant therapeutic challenges, necessitating ongoing exploration of innovative treatments. The use of antibody-drug conjugates (ADCs) represents an effective treatment strategy that combines the targeting capabilities of monoclonal antibodies with the cytotoxic effects of chemotherapeutic agents to deliver therapy directly to cancer cells. This article reviews recent advancements and the efficacy of ADCs in clinical trials and explores the mechanisms of resistance and the implications of ADC sequencing in treatment protocols. PEER REVIEWED ARTICLE **Peer reviewers:** Dr Bérénice Deletang, Clinique des Grangettes, Geneva, Switzerland One anonymous peer reviewer Received on May 16, 2024; accepted after peer review on September 12, 2024; published online on October 05, 2024.