Berberine-loaded PLGA nanoparticles alleviate ulcerative colitis by targeting IL-6/IL-6R axis
The BPL-NPs were confirmed to harbor anti-inflammatory effects both in vitro and in vivo, along with enhanced water solubility and bioactivity. In addition, the precise targeting of the IL-6/IL-6R axis was confirmed as the mechanism by which the BPL-NPs exerted therapeutic effects in UC, as demonstrated in both in vitro as well as in vivo studies.
Authors
- Tao Yang (ORCID: https://orcid.org/0000-0002-5787-2542)
- Qiming Gong (ORCID: https://orcid.org/0000-0002-0526-7041)
- Yihan Zhao (ORCID: https://orcid.org/0000-0001-6951-4809)
- Wanning Liu
- Xinhao Yan (ORCID: https://orcid.org/0000-0002-7233-8807)
- Chao Liu (ORCID: https://orcid.org/0000-0002-8595-0595)
Institutions
- Northwest University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12967-024-05682-x
- Citations
- 14
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 7.70
Funders
- National Natural Science Foundation of China