RNAi Knockdown of EHMT2 in Maternal Expression of Prader–Willi Syndrome Genes
RNAi reduction in EHMT2 activates maternally silenced PWS genes. Further studies are needed to determine whether the increase is therapeutically relevant. This study confirms the role of EHMT2 in the epigenetic regulation of PWS genes.
Authors
- Steven J. Gray (ORCID: https://orcid.org/0000-0002-6240-8621)
- Jeffrey M. Zigman (ORCID: https://orcid.org/0000-0003-3477-1295)
- Violeta Zaric
- Volodymyr Rybalchenko (ORCID: https://orcid.org/0000-0003-4092-0779)
- Ryan K. Butler (ORCID: https://orcid.org/0000-0002-5857-6489)
- Hye Ri Kang
Institutions
- Southwestern Medical Center (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Genes
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3390/genes15111366
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 0.00