Significance of neurodegeneration and neuroplasticity serum biomarkers in Parkinson’s disease patients treated with subthalamic stimulation
The ability of serum biomarkers to predict the prognosis and response to deep-brain stimulation (DBS) therapy in Parkinson's disease (PD) patients is promising. Here, we showed that NfL differed between healthy individuals and PD patients and that changes in NfL, GFAP, and BDNF occurred only transiently after DBS surgery. Therefore, subthalamic stimulation does not promote neurodegeneration, and these biomarkers do not serve as clinical improvement endpoints in PD DBS patients.
Authors
- Fátima Cano-Cano (ORCID: https://orcid.org/0000-0002-7290-0812)
- Francisco Escamilla‐Sevilla (ORCID: https://orcid.org/0000-0003-2149-2668)
- Elena Lozano-Soto (ORCID: https://orcid.org/0000-0002-8772-8584)
- Florencia Sanmartino (ORCID: https://orcid.org/0000-0003-0651-8890)
- Jesús Riqué-Dormido
- Raúl Rashid-López (ORCID: https://orcid.org/0000-0001-7319-4449)
- Álvaro Javier Cruz-Gómez (ORCID: https://orcid.org/0000-0001-9105-5100)
- Javier J. González-Rosa (ORCID: https://orcid.org/0000-0002-5609-1103)
- Raúl Espinosa‐Rosso (ORCID: https://orcid.org/0000-0002-0876-8378)
- F. Luis Sánchez-Fernández (ORCID: https://orcid.org/0000-0001-9517-5003)
- Paloma Macías-García (ORCID: https://orcid.org/0000-0003-2643-1127)
- Laura Gómez-Jaramillo
- Fernando López-Sosa (ORCID: https://orcid.org/0000-0002-0601-9103)
Institutions
- Universidad de Cádiz (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Biomedical Research and Innovation Institute of Cadiz (ES)
- Hospital Universitario Puerta del Mar (ES)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1038/s41531-024-00808-w
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Universidad de Cádiz
- European Regional Development Fund
- Agencia Estatal de Investigación