USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice
Our findings highlight Raptor and USP9X as promising molecular targets for therapeutic intervention in tauopathies. Targeting the USP9X-Raptor-mTORC1 axis may provide a novel strategy for promoting autophagy and mitigating tau pathology in Alzheimer's disease and other tauopathies.
Authors
- Yanmin Chang (ORCID: https://orcid.org/0000-0003-0296-2943)
- Hongxiu Guo
- Yanqing Wu (ORCID: https://orcid.org/0000-0003-3413-4130)
- Rong Ma (ORCID: https://orcid.org/0000-0001-8811-9003)
- Gang Li (ORCID: https://orcid.org/0000-0002-4549-293X)
- Siyi Zheng
- Jiahui Zhu (ORCID: https://orcid.org/0000-0003-2658-4924)
- Cailin Wang (ORCID: https://orcid.org/0000-0001-8050-2841)
- Shangqi Sun
Institutions
- Union Hospital (HK)
- Wuhan Puai Hospital (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12964-024-01872-8
- Citations
- 8
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- National Natural Science Foundation of China