Differentially Expressed Somatostatin (SST) and Its Receptors (SST1-5) in Sporadic Colorectal Cancer and Normal Colorectal Mucosa
Reduced SST expression in CRC indicates a weakening in its antitumor effect in this cancer in vivo. Overexpression of SST2 and SST5 in CRC suggests that these receptors play an important role in the pathogenesis of this cancer. Analysis of SST1-5 tissue expression allows for differentiation between the mucinous and nonmucinous CRC subtypes. The coexpression of all SST1-5 and overexpression of not only SST2 and SST5 in CRC may have applications for future therapy based on the SRIF system in sporadic CRC.
Authors
- Paulina Pietras (ORCID: https://orcid.org/0000-0002-8000-5471)
- Agnieszka Seraszek‐Jaros (ORCID: https://orcid.org/0000-0003-4787-1033)
- Aldona Kasprzak (ORCID: https://orcid.org/0000-0002-1773-3038)
- Marta Leśniczak-Staszak (ORCID: https://orcid.org/0000-0001-8687-4507)
- Witold Szaflarski (ORCID: https://orcid.org/0000-0001-5059-268X)
- Jacek Szmeja
- Agnieszka Geltz
- Małgorzata Andrzejewska (ORCID: https://orcid.org/0000-0003-4301-2557)
Institutions
- Poznan University of Medical Sciences (PL)
Publication Details
- Journal
- Cancers
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3390/cancers16213584
- Citations
- 2
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.77