Improved quality control of allergen products: Assessing the molecular allergen composition by mass spectrometry
This is the first study using a single consistent high-resolution LC-MS/MS method to provide solid data on the qualitative allergen composition of SPT and AIT products manufactured from various common allergen sources. The applied method showed high reliability in qualitative batch-to-batch consistency testing and can be performed fast and with high throughput. High-resolution LC-MS/MS is applicable for process development and quality control to ensure market availability of allergen products corresponding to the composition of the respective natural allergen sources.
Authors
- Oliver Pfaar (ORCID: https://orcid.org/0000-0003-4374-9639)
- Steffen Augustin (ORCID: https://orcid.org/0009-0009-3927-1645)
- Marek Jutel (ORCID: https://orcid.org/0000-0003-1555-9379)
- Martin Wald (ORCID: https://orcid.org/0000-0002-6558-1032)
- Frank Fischer (ORCID: https://orcid.org/0000-0002-5154-6594)
- Thomas Eichhorn
- Christoph Willers
Institutions
- Philipps University of Marburg (DE)
- Merck KGaA, Darmstadt (Germany) (DE)
- Wroclaw Medical University (PL)
Publication Details
- Journal
- Allergy
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1111/all.16339
- Citations
- 5
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 1.91
Funders
- Allergopharma