Blautia coccoides and its metabolic products enhance the efficacy of bladder cancer immunotherapy by promoting CD8+ T cell infiltration
This research provided valuable insights into enhancing the efficacy of PD-1 inhibitors in clinical settings. It was suggested that applying Blautia coccoides and its metabolic product, trigonelline, could serve as a synergistic treatment method with PD-1 inhibitors in clinical applications.
Authors
- Yao Yu (ORCID: https://orcid.org/0000-0002-2814-4482)
- Wentai Shangguan (ORCID: https://orcid.org/0000-0001-8103-9078)
- Peng Wu (ORCID: https://orcid.org/0000-0001-7140-5388)
- Benlin Wang (ORCID: https://orcid.org/0000-0002-8358-3154)
- Weijia Li (ORCID: https://orcid.org/0009-0009-2064-3437)
- Jingwen Xue (ORCID: https://orcid.org/0000-0002-5972-2329)
- Qi Sun (ORCID: https://orcid.org/0009-0001-3262-9802)
- Yuexuan Zhu
- Ming Xie (ORCID: https://orcid.org/0000-0002-5587-5272)
- Zhangrui Zhu
- Qishen Yang
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s12967-024-05762-y
- Citations
- 20
- Primary Topic
- Tannin, Tannase and Anticancer Activities
- Type
- article
- Field-Weighted Citation Impact
- 5.96
Funders
- National Natural Science Foundation of China