Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury <i>via</i> TXNIP regulation
Administration of GABA leads to the specific loading of miR-21-5p into EVs by ADSCs, thereby regulating the expression of TXNIP. The EVs derived from ADSCs treated with GABA effectively ameliorates mitochondrial oxidative stress and mitigates cardiomyocytes damage in the pathological process of MIRI.
Authors
- Yi Ding (ORCID: https://orcid.org/0000-0001-9294-8760)
- Chengyu Mao (ORCID: https://orcid.org/0000-0001-9740-8835)
- Zongqi Zhang (ORCID: https://orcid.org/0000-0001-6785-2038)
- Yuqi Fan
- Jianhong Zhou (ORCID: https://orcid.org/0000-0001-9829-8076)
- Tiantian Zhang (ORCID: https://orcid.org/0000-0002-5162-0408)
- Junfeng Zhang (ORCID: https://orcid.org/0000-0003-0150-6989)
- Jing Zhou (ORCID: https://orcid.org/0000-0003-3913-8341)
- En Zhou (ORCID: https://orcid.org/0000-0002-6073-8037)
- Fengdan Wang
- Qing He (ORCID: https://orcid.org/0000-0002-1078-350X)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2024-10-24
- DOI
- https://doi.org/10.4252/wjsc.v16.i10.873
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.94