A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures

Within biomedical engineering, there has been significant collaboration among clinicians, control engineers, and researchers to tailor treatments to individual patients. Anesthesia is integral to numerous medical procedures, necessitating precise management of hypnosis, analgesia, neuromuscular blockade, and hemodynamic variables. Recent attention has focused on computer-controlled anesthesia and hemodynamic stabilization. This research proposes the integration of a decentralized control strategy for the induction phase with a decoupled control approach for the maintenance phase, aimed at mitigating interactions within the multivariable human system. The proposed strategy is based on fractional-order controllers. The solution is validated using an open-source patient simulator featuring data from 24 virtual patients, demonstrating the efficiency of the proposed approach with respect to decentralized control.