Mesenchymal Stem Cells Engineered by Multicomponent Coassembled DNA Nanofibers for Enhanced Wound Healing

A major challenge for stem cell therapies, such as using mesenchymal stem cells to treat skin injuries, is the stable engraftment of exogenous cells and the maintenance of their regenerative capacities in the wound areas. DNA-based self-assembly strategies can be used for artificial and multifunctional cell surface engineering to stabilize and enhance their functions for therapeutic applications. Here, we developed DNA nanofiber-decorated stem cells, in which DNA-based, multivalent fiber-like structures were self-assembled in situ on the cell surfaces. These engineered stem cells have demonstrated robust reactive oxygen species (ROS) scavenging effects, specific adhesion to damaged vascular endothelial cells, and the ability to enhance angiogenesis, which were effective and safe for acute or chronic wound healing in a mouse model with excisional skin injury. This DNA nanostructure-engineered stem cell provides a novel therapeutic platform for the treatment of tissue damage.

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Publication Details

Journal
Nano Letters
Published
2024-10-24
DOI
https://doi.org/10.1021/acs.nanolett.4c03144
Citations
2
Primary Topic
Electrospun Nanofibers in Biomedical Applications
Type
article
Field-Weighted Citation Impact
0.35

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article

Mesenchymal Stem Cells Engineered by Multicomponent Coassembled DNA Nanofibers for Enhanced Wound Healing

Zhuoting Li, Baoquan Ding, Yushuai Wu, Robert Chunhua Zhao et al.
2 citations
Nano Letters
Electrospun Nanofibers in Biomedical Applications
0.35
article

Mesenchymal Stem Cells Engineered by Multicomponent Coassembled DNA Nanofibers for Enhanced Wound Healing

Zhuoting Li, Baoquan Ding, Yushuai Wu, Robert Chunhua Zhao, Jing Li, Yiming Wang, Qin Han, Shuaijing Ma, Qiao Jiang, Fengsong Liu, Run Tian
article en
2 citations

Abstract

A major challenge for stem cell therapies, such as using mesenchymal stem cells to treat skin injuries, is the stable engraftment of exogenous cells and the maintenance of their regenerative capacities in the wound areas. DNA-based self-assembly strategies can be used for artificial and multifunctional cell surface engineering to stabilize and enhance their functions for therapeutic applications. Here, we developed DNA nanofiber-decorated stem cells, in which DNA-based, multivalent fiber-like structures were self-assembled in situ on the cell surfaces. These engineered stem cells have demonstrated robust reactive oxygen species (ROS) scavenging effects, specific adhesion to damaged vascular endothelial cells, and the ability to enhance angiogenesis, which were effective and safe for acute or chronic wound healing in a mouse model with excisional skin injury. This DNA nanostructure-engineered stem cell provides a novel therapeutic platform for the treatment of tissue damage.

Nano LettersVol. 24(44)
Academy of Medical Sciences (GB), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Center for NanoScience (DE), Sino-Danish Centre for Education and Research (CN), National Center for Nanoscience and Technology (CN), University of Chinese Academy of Sciences (CN), Academia Sinica (TW)
National Natural Science Foundation of China, Youth Innovation Promotion Association of the Chinese Academy of Sciences
Zero hunger
Openalex Percentile: Top 43%
Electrospun Nanofibers in Biomedical Applications
0.35
DOISourceOpenAlex
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