SARS-CoV-2 NSP6 reduces autophagosome size and affects viral replication via sigma-1 receptor
We have provided a preliminary explanation of the effects on autophagy of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structure protein 6 from the pre-autophagic and late stages, and also found that sigma-1 receptor is likely to be used as a potential target for SARS-CoV-2 therapy to develop relevant drugs.
Authors
- Yiquan Li (ORCID: https://orcid.org/0000-0002-6795-6088)
- Lisen Lin (ORCID: https://orcid.org/0000-0003-4060-8881)
- Zhuo Hao (ORCID: https://orcid.org/0000-0001-7723-3871)
- Dapeng Li (ORCID: https://orcid.org/0009-0002-8402-6461)
- Chao Shang (ORCID: https://orcid.org/0000-0002-7563-8899)
- Qiwei Jiang (ORCID: https://orcid.org/0000-0002-6048-0582)
- Gaojie Song (ORCID: https://orcid.org/0000-0001-5233-465X)
- Yan Liu (ORCID: https://orcid.org/0009-0006-6359-2615)
- Minghua Chen (ORCID: https://orcid.org/0000-0001-5634-4599)
- Cuiling Zhang (ORCID: https://orcid.org/0000-0003-3370-7021)
- Nan Li (ORCID: https://orcid.org/0000-0002-6408-1773)
- Zirui Liu (ORCID: https://orcid.org/0000-0001-9498-8387)
- Xiao Li
Institutions
- Jiujiang University (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Changchun University of Chinese Medicine (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Northeastern University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1128/jvi.00754-24
- Citations
- 8
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Natural Science Foundation of Jilin Province
- National Natural Science Foundation of China
- People's Government of Jilin Province