High chloride induces aldosterone resistance in the distal nephron
These findings indicate a pivotal role for extracellular [Cl<sup>-</sup>] in modulating renal aldosterone signaling to adapt MR activation by a high K<sup>+</sup> intake to the NaCl balance. An impairment of [Cl<sup>-</sup>]-mediated aldosterone resistance may contribute to excessive MR activation by aldosterone in the presence of a high salt intake characteristic of the Western diet, resulting in an inappropriate salt reabsorption and its downstream detrimental effects.
Authors
- Heimo Ehmke (ORCID: https://orcid.org/0000-0003-3465-7185)
- Catherine Meyer‐Schwesinger
- Hung Pham (ORCID: https://orcid.org/0000-0002-7055-3108)
- Helga Vitzthum (ORCID: https://orcid.org/0009-0003-2393-9715)
- Nina Hauswald
- Leya Eckermann‐Reimer
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1111/apha.14246
- Citations
- 1
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung