A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows
Livers can be reproducibly perfused in excess of 120 (range 121-184) hours with evidence of preserved hepatocyte and cholangiocyte function.
Authors
- M. Thamara P. R. Perera (ORCID: https://orcid.org/0000-0002-5417-3850)
- Angus Hann (ORCID: https://orcid.org/0000-0003-4431-3642)
- Jingwen Mao (ORCID: https://orcid.org/0000-0001-7467-8461)
- Amita Gupta (ORCID: https://orcid.org/0000-0001-7036-2718)
- Yiyu Fan
- Nick Murphy (ORCID: https://orcid.org/0000-0001-8074-1447)
- Alexander J. Lawson (ORCID: https://orcid.org/0000-0002-8587-6540)
- Hynek Mergental (ORCID: https://orcid.org/0000-0001-5480-9380)
- Anisa Nutu (ORCID: https://orcid.org/0000-0003-4699-0970)
- Mansoor N. Bangash (ORCID: https://orcid.org/0000-0001-5039-5184)
- Simon C. Afford (ORCID: https://orcid.org/0000-0003-2858-3319)
- Kayani Kayani (ORCID: https://orcid.org/0000-0002-8122-3139)
- B. Dasari (ORCID: https://orcid.org/0000-0003-2375-1141)
- George L. Clarke (ORCID: https://orcid.org/0000-0002-8913-398X)
- A.L. Casey
- Isla Wootton
- Erwin Buckel Schaffner
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- National Institute for Health and Care Research (GB)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1038/s43856-024-00636-2
- Citations
- 4
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Wellcome Trust
- Medical Research Council