Mapping the locus for ocular melanosis in Cairn Terriers
OM in Cairn Terriers maps to a 1.49 Mb region of chromosome 11. This accounts for 86% of OM cases in our DNA bank. A second locus may account for the OM phenotype in the remaining 14% of cases. Sequencing of coding regions and splice sites of positional candidate genes and a microRNA did not reveal any genetic variants unique to affected dogs. Further studies are required to elucidate the DNA variant causal for OM in Cairn Terriers and to understand the disease mechanism.
Authors
- Paige A. Winkler (ORCID: https://orcid.org/0000-0001-9646-2995)
- Ethan M. Dawson‐Baglien (ORCID: https://orcid.org/0000-0003-1624-9196)
- Simon M. Petersen‐Jones (ORCID: https://orcid.org/0000-0002-7410-2304)
- M.P. Coffey (ORCID: https://orcid.org/0000-0003-4890-6218)
- Patrick J. Venta
- Kari J. Ekenstedt (ORCID: https://orcid.org/0000-0002-3213-7883)
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Veterinary Ophthalmology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1111/vop.13291
- Primary Topic
- Veterinary Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Morris Animal Foundation
- American Kennel Club Canine Health Foundation