The effect of high protein dosing in critically ill patients: an exploratory, secondary Bayesian analyses of the EFFORT Protein trial
We found moderate to high probabilities of harm with high protein doses compared with usual protein in ICU patients for the primary and secondary outcomes. We found suggestions of heterogeneity in treatment effects with worse outcomes in participants randomised to high protein doses with renal dysfunction or acute kidney injury and greater illness severity at baseline.
Authors
- Daren K. Heyland (ORCID: https://orcid.org/0000-0002-6440-4616)
- John Richard Prowle (ORCID: https://orcid.org/0000-0002-5002-2721)
- Danielle E. Bear (ORCID: https://orcid.org/0000-0001-5211-5553)
- Andrew G. Day (ORCID: https://orcid.org/0000-0002-1095-5703)
- Zudin Puthucheary (ORCID: https://orcid.org/0000-0003-4267-1892)
- Anders Granholm (ORCID: https://orcid.org/0000-0001-5799-7655)
- Ryan W. Haines (ORCID: https://orcid.org/0000-0002-4864-2825)
Institutions
- Queen Mary University of London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Queen's University (CA)
- Barts Health NHS Trust (GB)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Clinical Evaluation Research Unit (CA)
- William Harvey Research Institute (GB)
- Kingston Health Sciences Centre (CA)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.bja.2024.08.033
- Citations
- 7
- Primary Topic
- Hemodynamic Monitoring and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Astute Medical
- Fresenius Medical Care North America
- Novo Nordisk