Interaction Between PNPLA3 and SIRT5 Genetic Variants in Association with Liver Fibrosis Severity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
Our data indicate that the <i>PNPLA3</i> and <i>SIRT5</i> polymorphisms were independently and additively linked to significant fibrosis, while the <i>HSD17B13</i> polymorphism was associated with increased steatosis in Thai populations. These data might emphasize the importance of genetic variants in progressive MASLD.
Authors
- Bootsakorn Boonkaew (ORCID: https://orcid.org/0000-0002-9548-1059)
- Chalermrat Bunchorntavakul (ORCID: https://orcid.org/0000-0002-8842-032X)
- Pornjira Somnark (ORCID: https://orcid.org/0000-0002-7687-4930)
- Pisit Tangkijvanich (ORCID: https://orcid.org/0000-0002-2926-8671)
- Kamonchanok Moonlisarn
Institutions
- Chulalongkorn University (TH)
- Rajavithi Hospital (TH)
Publication Details
- Journal
- Genes
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3390/genes15111370
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Chulalongkorn University
- Faculty of Medicine, Chulalongkorn University