Glymphatic system, sleep, neurodegeneration

The prevalence of neurodegenerative diseases and the complexity of their treatment in late stages make it urgent to identify early markers and symptoms of this group of diseases in order to optimize diagnosis, treatment and prevention. Materials and methods. The PubMed database was analyzed for the following queries: perivascular space, Virchow–Robin space, glymphatic system, sleep disorders, Alzheimer’s disease. Conclusion: enlargement of perivascular spaces (Virchow–Robin) can be considered an early structural marker of both glymphatic dysfunction and neurodegenerative diseases, while sleep disturbance can be considered as a functional marker (symptom) of these disorders.