The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis
Our findings have uncovered an important role of SRXN1 and protein S -sulfinylation in HSC activation and liver fibrosis. The SRXN1-PTPN12-NLRP3 axis represents potential therapeutic targets for liver fibrosis.
Authors
- Yun Soo Bae (ORCID: https://orcid.org/0000-0002-9944-3180)
- Pengfei Xu (ORCID: https://orcid.org/0000-0001-6854-6040)
- Mengyun Ke (ORCID: https://orcid.org/0000-0002-2534-9669)
- Kate S. Carroll (ORCID: https://orcid.org/0000-0002-7624-9617)
- Yixian Huang (ORCID: https://orcid.org/0009-0004-2601-2875)
- Wen Li Xie (ORCID: https://orcid.org/0000-0003-3967-155X)
- Xinran Cai (ORCID: https://orcid.org/0000-0003-4562-3538)
- Song Li (ORCID: https://orcid.org/0000-0003-1658-949X)
- Yue Xi (ORCID: https://orcid.org/0000-0003-1265-6624)
- Songrong Ren (ORCID: https://orcid.org/0000-0001-6797-6188)
- Hung‐Chun Tung (ORCID: https://orcid.org/0000-0002-9854-6831)
- Arijit Bhowmik (ORCID: https://orcid.org/0000-0001-8321-9996)
- Jong‐Won Kim (ORCID: https://orcid.org/0009-0008-1219-6967)
- Meishu Xu
Institutions
- Ewha Womans University (KR)
- University of Pittsburgh (US)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
Publication Details
- Journal
- Hepatology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1097/hep.0000000000001133
- Citations
- 6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.32