CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants
Variants in GBA1 result in dysregulated sphingolipids. We investigated five CSF d18:1 sphingolipid species in a longitudinal multicenter cohort comprising people with Parkinson's Disease and Dementia with Lewy bodies with and without GBA1 variants and healthy controls. We found no increase of sphingolipid species in heterozygous GBA1 variant participants and no effect on development of cognitive impairment. Thus, CSF d18:1 sphingolipids are not suitable as state markers in Parkinson's Disease.
Authors
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Stefanie Lerche (ORCID: https://orcid.org/0000-0002-5508-004X)
- Ariadna Laguna (ORCID: https://orcid.org/0000-0002-9732-6677)
- Carrolee Barlow
- Per Svenningsson (ORCID: https://orcid.org/0000-0001-6727-3802)
- Marta Martínez‐Vicente (ORCID: https://orcid.org/0000-0001-7053-2625)
- Andrea Sturchio (ORCID: https://orcid.org/0000-0002-1067-2834)
- Daniela Samaniego (ORCID: https://orcid.org/0000-0001-8362-0747)
- Jorge Hernández‐Vara (ORCID: https://orcid.org/0000-0002-9129-5224)
- Enza Maria Valente (ORCID: https://orcid.org/0000-0002-0600-6820)
- Isabel Wurster (ORCID: https://orcid.org/0000-0003-0157-5722)
- Sethu Sankaranarayanan (ORCID: https://orcid.org/0000-0002-3380-6532)
- Micol Avenali (ORCID: https://orcid.org/0000-0002-7880-9921)
- Nicholas P. France
Institutions
- University of Pavia (IT)
- German Center for Neurodegenerative Diseases (DE)
- Karolinska Institutet (SE)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Centre for Movement Disorders (CA)
- Escape Therapeutics (United States) (US)
- Hertie Institute for Clinical Brain Research (DE)
- Research Network (United States) (US)
- University of Tübingen (DE)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1038/s41531-024-00820-0
- Citations
- 3
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Eberhard Karls Universität Tübingen
- Bundesministerium für Bildung und Forschung
- Ministero della Salute
- Kommunfullmäktige, Stockholms Stad
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Instituto de Salud Carlos III