Recognition of Hyperinsulinaemic Hypoglycaemia in Infants with Congenital Central Hypoventilation Syndrome
Patients with CCHS, due to PHOX2B mutations, may experience both fasting and postprandial hypoglycaemia, necessitating treatment for HH. Clinicians should screen children with CCHS for hypoglycaemia symptoms to quickly identify those affected by HH, initiate prompt treatment, and prevent potential brain injury from severe hypoglycaemia. The severity of hypoglycaemia due to HH tends to decrease over time, with glycaemic resolution potentially being achieved over several years.
Authors
- Antonia Dastamani (ORCID: https://orcid.org/0000-0002-6332-3136)
- Daphne Yau (ORCID: https://orcid.org/0000-0002-3559-6479)
- Neha Malhotra (ORCID: https://orcid.org/0000-0002-0494-3896)
- Clare Gilbert (ORCID: https://orcid.org/0000-0003-4426-1045)
- Thia Hanania
- Indraneel Banerjee (ORCID: https://orcid.org/0000-0003-4280-7470)
- Martin Samuels (ORCID: https://orcid.org/0000-0002-9811-8335)
- Emma Wakeling (ORCID: https://orcid.org/0000-0001-5712-0044)
- Kate Morgan
- Wendy D Jones
Institutions
- Great Ormond Street Hospital (GB)
- University of Saskatchewan (CA)
- Basildon Hospital (GB)
- Royal Manchester Children's Hospital (GB)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1159/000542234
- Citations
- 1
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 0.36