Treatment with novel topoisomerase inhibitors in Ewing sarcoma models reveals heterogeneity of tumor response
Our findings suggest that IIQs may be promising new agents for a subset of EWS patients.
Authors
- Deborah B. Householder
- Melanie B. Gordon
- Christine M. Heske (ORCID: https://orcid.org/0000-0003-0956-6249)
- Kristine Johnson
- Cody J. Peer (ORCID: https://orcid.org/0000-0001-9395-3473)
- Fathi Elloumi (ORCID: https://orcid.org/0009-0007-7116-508X)
- Ludmila Szabova (ORCID: https://orcid.org/0000-0002-5194-0604)
- S. Jorgensen
- Ryan D. Roberts (ORCID: https://orcid.org/0000-0001-5028-744X)
- Sudhir Varma (ORCID: https://orcid.org/0000-0001-6793-9344)
- Unsun Lee (ORCID: https://orcid.org/0000-0002-9305-5371)
- Sophia Varriano (ORCID: https://orcid.org/0000-0001-9174-9321)
- Victor J. Collins (ORCID: https://orcid.org/0000-0002-5310-7034)
- Yves Pommier (ORCID: https://orcid.org/0000-0002-3108-0758)
- Shyam K. Sharan (ORCID: https://orcid.org/0000-0002-9333-870X)
- Zoë Weaver Ohler (ORCID: https://orcid.org/0000-0002-6287-2504)
- Laura Bassel (ORCID: https://orcid.org/0000-0003-1684-6839)
- Lucy Lu (ORCID: https://orcid.org/0000-0002-6368-3721)
- William D. Figg (ORCID: https://orcid.org/0000-0003-2428-5613)
- Ariana E. Nelson (ORCID: https://orcid.org/0009-0005-2813-3459)
Institutions
- National Institutes of Health (US)
- Nationwide Children's Hospital (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.3389/fcell.2024.1462840
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Institute
- St. Jude Children's Research Hospital
- National Institutes of Health