Glutamate dehydrogenase 1-catalytic glutaminolysis feedback activates EGFR/PI3K/AKT pathway and reprograms glioblastoma metabolism
These findings suggest a novel function of glutaminolysis in the regulation of signal transduction and metabolism reprogramming and provide further evidence for the unique role of glutaminolysis in GBM progression.
Authors
- Rui Yang (ORCID: https://orcid.org/0000-0002-0525-1728)
- Zhen Meng
- Siyuan Yan (ORCID: https://orcid.org/0000-0002-4127-904X)
- Hongjuan Cui (ORCID: https://orcid.org/0000-0003-1178-1570)
- Yanping Li (ORCID: https://orcid.org/0000-0002-0412-2748)
- Shanshan Wang (ORCID: https://orcid.org/0000-0002-0575-6523)
- Guanghui Zhang (ORCID: https://orcid.org/0000-0002-5854-6909)
- Haibin Li (ORCID: https://orcid.org/0000-0002-6932-982X)
- Xiaonan Wei
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- Southwest University (CN)
- Liaocheng University (CN)
- First Affiliated Hospital of Henan University (CN)
- Chongqing University of Technology (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1093/neuonc/noae222
- Citations
- 18
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.13