Ru-Catalyzed Redox-Neutral Coupling of <i>N</i>-Chlorobenzamides with Unsymmetrical Alkynes in Water
In water, Ru-catalyzed annulation of <i>N</i>-chlorobenzamides with unsymmetrical internal alkynes bearing aryl, hydroxy, ester, and sulfonyl functionalities has been accomplished to afford isoquinolone scaffolds under external oxidant-free conditions at room temperature. Use of water as reaction medium, redox-neutral conditions, regioselectivity, and substrate scope are important practical features.
Authors
- Tharmalingam Punniyamurthy (ORCID: https://orcid.org/0000-0003-4696-8896)
- Sharajit Saha (ORCID: https://orcid.org/0009-0005-1062-8613)
- Subhankar Dolai
- Swati Samantaray (ORCID: https://orcid.org/0000-0002-4823-9278)
- Kshitiz Verma (ORCID: https://orcid.org/0000-0001-8496-2829)
- Hemanga Bhattacharyya (ORCID: https://orcid.org/0009-0005-3357-1138)
Institutions
- Indian Institute of Technology Guwahati (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1021/acs.joc.4c02234
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Ministry of Education, India
- Science and Engineering Research Board